Please ensure Javascript is enabled for purposes of website accessibility Biostimulators, Botox, and Fillers: What’s the Difference? - Eugenie Brunner, M.D., F.A.C.S

When it comes to facial rejuvenation, there are more options than ever to restore volume, smooth wrinkles, and improve skin quality. Among the most popular treatments are biostimulators, Botox, and dermal fillers. While these injectables may seem similar, they work in distinct ways to achieve different aesthetic goals. 

At Dr. Eugenie Brunner’s medical spa in Princeton, NJ, we offer all three options to help you achieve a naturally youthful, refreshed appearance. Let us break down how each treatment works, what it’s best for, and how to choose the right approach for your needs.

The Difference Between Botox, Fillers, and Biostimulators

While all of these treatments help restore a youthful appearance, they function very differently. Botox (neuromodulators) temporarily relax muscles to smooth dynamic wrinkles caused by facial expressions, making them ideal for treating forehead lines, crow’s feet, and frown lines. 

Dermal fillers like Restylane®JUVÉDERM® and RHA add volume to areas affected by age-related volume loss, helping to plump lips, contour cheeks, and define the jawline without affecting muscle movement. 

Biostimulators (Radiesse, Radiesse with PRP and Sculptra), on the other hand, don’t just provide instant improvement. Their effects increase over time by stimulating collagen production, resulting in gradual, long-lasting skin rejuvenation and improved texture and volume.

Botox

Botox addresses the lines and creases that form due to repeated facial movements, such as smiling, frowning, or squinting. By inhibiting muscle contractions, Botox softens wrinkles and prevents them from deepening over time.

before and after botox in princeton

Best Uses for Botox:

  • Smoothing crow’s feet, forehead lines, and frown lines
  • Slimming the jawline by relaxing the masseter muscles
  • Reducing chin dimpling and neckbands
  • Preventing future wrinkles with early treatments

How Long Do Results Last?

Botox results typically last 3-4 months, depending on the area treated and individual factors.

Dermal Fillers

Dermal fillers are gel-like substances that restore lost volume, sculpt facial contours, and smooth deep wrinkles. Most fillers are made from hyaluronic acid (HA), a naturally occurring substance that keeps skin hydrated and plump.

doctor examining patient before treatment

Best Uses for Dermal Fillers:

  • Enhancing lips, cheeks, and chin
  • Contouring the jawline
  • Filling deep lines (nasolabial folds, marionette lines)
  • Restoring lost volume in the temples and under the eyes

How Long Do Results Last?

  • HA fillers last 6-12 months, depending on the product and area treated.
  • RHA 2, RHA 3, and RHA 4 last up to 15 months each.  

Biostimulators

Biostimulators go beyond traditional fillers by encouraging your skin to produce its own collagen. Over time, they enhance skin structure, improve elasticity, and provide long-lasting volume restoration.

Radiesse®

Radiesse contains calcium hydroxylapatite (CaHA) microspheres, which stimulate collagen production. It provides immediate volume while gradually improving skin quality over time. When combined with platelet-rich plasma (PRP) or platelet-rich fibrin (PRF), Radiesse offers even more powerful rejuvenation, helping to tighten skin and enhance overall radiance.

 

Results last: 15+ months

Before and after sculptra treatment in princeton, NJ

Sculptra®

Sculptra is composed of poly-L-lactic acid, which gradually stimulates collagen production. Unlike traditional fillers, results develop over several months, providing a natural-looking enhancement in skin texture, volume, and firmness.

Results last: 2+ years with proper maintenance.

Dr. Brunner prepping a patient for cosmetic treatment

EZ PRF®

EZ PRF is a cutting-edge regenerative treatment that uses platelet-rich fibrin (PRF) and Albumin to promote tissue repair and collagen synthesis. Unlike PRP, EZ PRF contains 3-5 times more platelets, making it a highly potent biostimulator that delivers longer-lasting skin rejuvenation.

Results last: Varies but typically longer than PRP.

Before and after EZ PRF treatment in Princeton NJ

Which Treatment Is Right for You?

Choosing between Botox, fillers, and biostimulators depends on your unique concerns and aesthetic goals:

  • Want to smooth dynamic wrinkles? Botox is the best choice.
  • Looking to add volume and contour? Dermal fillers offer instant enhancement.
  • Interested in long-term skin rejuvenation? Biostimulators help restore collagen for natural, lasting results.

During a consultation at Dr. Brunner’s Princeton office, we will customize a treatment plan for your facial structure, skin condition, and desired outcome.

Rejuvenate Your Look with Expert Care

Dr. Eugenie Brunner is renowned for delivering natural-looking, sophisticated results through advanced injectable treatments. Whether you’re looking to soften fine lines, enhance facial contours, or restore youthful volume, she will create a customized plan that enhances your natural beauty.

Ready to refresh your look? 

Contact our office today to schedule a consultation and explore your best treatment options.